Colon LC-MSMS of Mouse with experimental colitis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Colon
SUBMITTER: 
Lei Hu
LAB HEAD: Songlin wang
PROVIDER: PXD026228 | Pride | 2022-02-17
REPOSITORIES: Pride
Publications
Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3.
Hu Lei L Xu Junji J Wang Xue X Feng Liang L Zhang Chunmei C Wang Jinsong J Wang Songlin S
Frontiers in cell and developmental biology 20211006
Damage to intestinal epithelial cell proliferation or intestinal stem cell (ISC) maintenance may trigger inflammatory bowel disease (IBD), and protecting the ISCs is critical for IBD treatment. Here, we found that in the dextran sulfate sodium (DSS)-induced ulcerative colitis mice model, colon epithelium and Lgr5<sup>+</sup> intestinal stem cells (ISCs) renew quickly during the first 3 days. We also found that during this renewing period, SMAD4 and bone morphogenetic protein 4 (BMP4) expression ...[more]
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