Proteomics

Dataset Information

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Brain tissus of Oryzias melastigma under hypoxia, rep1


ABSTRACT: Hypoxia is amongst the most widespread and pressing problems in aquatic environments. Here we demonstrate that fish (Oryzias melastigma) exposed to hypoxia show reproductive impairments (retarded gonad development, decrease in sperm count and sperm motility) in F1 and F2 generations despite these progenies (and their germ cells) having never been exposed to hypoxia. We further show that the observed transgenerational reproductive impairments are associated with a differential methylation pattern of specific genes in sperm of both F0 and F2 coupled with relevant transcriptomic and proteomic alterations, which may impair spermatogenesis.

INSTRUMENT(S): frag: iTRAQ 8plex reporter ion

ORGANISM(S): Oryzias Latipes (japanese Rice Fish) (japanese Killifish)

TISSUE(S): Brain

SUBMITTER: Tong Yin  

LAB HEAD: Dr. Ball KP LAI

PROVIDER: PXD026257 | Pride | 2021-05-25

REPOSITORIES: Pride

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