Proteomics

Dataset Information

0

Gestational chronodisruption throughout pregnancy impairs adipose tissue physiology in the offspring

ABSTRACT: Compelling evidence supports that gestational chronodisruption induces major changes in maternal circadian rhythms, fetal development and that these changes impact adult life at many physiological levels. Using a rat model of chronic photoperiod shifting throughout gestation (CPS), we investigated the detrimental effects of gestational CPS on glucose homeostasis, adipose tissue physiology and metabolism in the adult male offspring. At proteomic level, in CPS adipose tissue, 275 proteins displayed differential expression, compared with LD animals fed with a standard diet. Interestingly, CPS offspring and LD fed with HFD showed 20 proteins in common (2 upregulated 18 downregulated). Based on these common proteins, the IPA analysis found that 2 functional pathways were significantly altered; the network 1 (AKT/ERK) and the network 2 (TNF/IL4).

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): White Adipose Tissue

SUBMITTER: Thilo Kaehne  

LAB HEAD: Prof. Dr. Thilo Kaehne

PROVIDER: PXD026315 | Pride | 2021-08-11

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Maternal Chronodisruption Throughout Pregnancy Impairs Glucose Homeostasis and Adipose Tissue Physiology in the Male Rat Offspring.

Halabi Diego D   Richter Hans G HG   Mendez Natalia N   Kähne Thilo T   Spichiger Carlos C   Salazar Esteban E   Torres Fabiola F   Vergara Karina K   Seron-Ferre Maria M   Torres-Farfan Claudia C  

Frontiers in endocrinology 20210816

Compelling evidence in rats support the idea that gestational chronodisruption induces major changes in maternal circadian rhythms and fetal development and that these changes impact adult life at many physiological levels. Using a model of chronic photoperiod shifting throughout gestation (CPS), in which pregnant female rats (Sprague-Dawley strain; <i>n</i> = 16 per group) were exposed to lighting schedule manipulation every 3-4 days reversing the photoperiod completely or light/dark photoperio  ...[more]

Similar Datasets

Unknown Expression profile of rat kidney of fetuses with 19 days of gestation under chronic rotation of the photoperiod.
2019-06-06 | GSE130744 | GEO
Transcriptomics Clariom S mouse arrays of C57Bl6/NTac mice to analyse how obesogenic diet exposure of parents induces sex-specific programming of overweight in mouse offspring
2023-11-30 | E-MTAB-13493 | biostudies-arrayexpress
Unknown Gestational diabetes adversely affects pancreatic islet development and function in the rat offspring
2019-12-31 | GSE116663 | GEO
Unknown mRNA expression in white adipose tissue of adult F2 female offspring from F0-fathers fed a chow or high-fat diet
2017-01-01 | GSE65182 | GEO
Unknown Gestational diabetes in mice induces hematopoietic memory that impacts the long-term health of the offspring
2023-11-13 | GSE244697 | GEO
Unknown Gestational diabetes in mice induces hematopoietic memory that impacts the long-term health of the offspring.
2023-11-13 | GSE244695 | GEO
Unknown Gestational diabetes in mice induces hematopoietic memory that impacts the long-term health of the offspring.
2023-11-13 | GSE244688 | GEO
Genomics Maternal Nutrition Induces Pervasive Gene Expression Changes but no Detectable DNA Methylation Differences in the Liver of Adult Offspring [RRBS]
2014-03-04 | E-GEOD-52266 | biostudies-arrayexpress
Genomics Maternal Nutrition Induces Pervasive Gene Expression Changes but no Detectable DNA Methylation Differences in the Liver of Adult Offspring [selected loci]
2014-03-04 | E-GEOD-52267 | biostudies-arrayexpress
Transcriptomics Genome-wide analysis of gene expression in adipose tissue of female mice after continuous high fat diet feeding
2013-05-10 | E-GEOD-37238 | biostudies-arrayexpress