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Acetylated proteomic identification of stored platelets

ABSTRACT: In this project, the protein acetylation levels in human platelets and in WT and SIRT3-/- mouse platelets during storage were examined.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Blood Platelet, Blood Cell

SUBMITTER: Xuemei Fan

LAB HEAD: Junling Liu

PROVIDER: PXD026341 | Pride | 2022-06-09

REPOSITORIES: Pride

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CPT2 K79 acetylation regulates platelet life span.

Fan Xuemei X Wang Yang Y Cai Xiaohong X Shen Yingzhi Y Xu Tongran T Xu Yanyan Y Cheng Jinke J Wang Xuefeng X Zhang Lin L Dai Jing J Lin Shuhai S Liu Junling J

Blood advances 20220901 17

The short life span of platelets is a major challenge to platelet transfusion services because of the lack of effective intervention. Here, we found that the accumulation of long-chain acylcarnitines (LCACs) is responsible for mitochondrial damage and platelet storage lesion. Further studies showed that the blockade of fatty acid oxidation and the activation of AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase/carnitine palmitoyltransferase 1 (CPT1) pathways that promote fatty acid meta ...[more]

PMID: 35728063

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