Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro, Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Fibroblast
SUBMITTER: Jarrod Sandow
LAB HEAD: James Vince
PROVIDER: PXD026533 | Pride | 2022-08-12
REPOSITORIES: Pride
Frank Daniel D Garnish Sarah E SE Sandow Jarrod J JJ Weir Ashley A Liu Lin L Clayer Elise E Meza Lizeth L Rashidi Maryam M Cobbold Simon A SA Scutts Simon R SR Doerflinger Marcel M Anderton Holly H Lawlor Kate E KE Lalaoui Najoua N Kueh Andrew J AJ Eng Vik Ven VV Ambrose Rebecca L RL Herold Marco J MJ Samson Andre L AL Feltham Rebecca R Murphy James M JM Ebert Gregor G Pearson Jaclyn S JS Vince James E JE
iScience 20220617 7
Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of RIPK3 is not fully understood. Using mass-spectrometry, we identified that RIPK3 is ubiquitylated on K469. The expression of mutant RIPK3 K469R demonstrated that RIPK3 ubiquitylation can limit both RIPK3-mediated apoptosis and necroptosis. The enhanced cell de ...[more]