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Liver proteomics identifies metabolic pathways affected by pantothenic acid deficiency in Pekin ducks

ABSTRACT: We characterized the liver proteome of six Pekin ducks from pantothenic acid-deficient (PAD) group and the pantothenic acid-adequate (control, CON) group.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Anas Platyrhynchos

TISSUE(S): Liver

SUBMITTER: Jing Tang

LAB HEAD: Shuisheng Hou

PROVIDER: PXD026607 | Pride | 2022-10-14

REPOSITORIES: Pride

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Integrated liver proteomics and metabolomics identify metabolic pathways affected by pantothenic acid deficiency in Pekin ducks.

Tang Jing J Wu Yongbao Y Zhang Bo B Liang Suyun S Guo Zhanbao Z Hu Jian J Zhou Zhengkui Z Xie Ming M Hou Shuisheng S

Animal nutrition (Zhongguo xu mu shou yi xue hui) 20220621

Pantothenic acid deficiency (PAD) in animals causes growth depression, fasting hypoglycemia and impaired lipid and glucose metabolism. However, a systematic multi-omics analysis of effects of PAD on hepatic function has apparently not been reported. We investigated liver proteome and metabolome changes induced by PAD to explain its effects on growth and liver metabolic disorders. Pekin ducks (1-d-old, <i>n</i> = 128) were allocated into 2 groups, with 8 replicates and 8 birds per replicate. For ...[more]

PMID: 35950191

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