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Surface proteome of large extracellular vesicles

ABSTRACT: The extracellular vesicle (EV) surface proteome (surfaceome) acts as a fundamental signalling gateway by bridging intra-and extracellular signalling networks, dictates EVs’ capacity to communicate and interact with its the/their environment, and is a source of potential disease biomarkers and therapeutic targets. However, our understanding of surface protein composition of large EVs (100-1000 nm), a major EV-subtype remains limited. Our study provides critical insights into proteins operating at the large interactive platform of L-EVs, and molecular leads for future studies seeking to decipher relatively-understudied L-EV form, heterogeneity and function.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell

DISEASE(S): Disease Free

SUBMITTER: david greening

LAB HEAD: David Greening

PROVIDER: PXD026658 | Pride | 2021-11-17

REPOSITORIES: Pride

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