Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Rasmus Ree
LAB HEAD: Thomas Arnesen
PROVIDER: PXD026684 | Pride | 2021-08-17
REPOSITORIES: Pride
Kweon Hyae Yon HY Lee Mi-Ni MN Dorfel Max M Seo Seungwoon S Gottlieb Leah L PaPazyan Thomas T McTiernan Nina N Ree Rasmus R Bolton David D Garcia Andrew A Flory Michael M Crain Jonathan J Sebold Alison A Lyons Scott S Ismail Ahmed A Marchi Elaine E Sonn Seong-Keun SK Jeong Se-Jin SJ Jeon Sejin S Ju Shinyeong S Conway Simon J SJ Kim Taesoo T Kim Hyun-Seok HS Lee Cheolju C Roh Tae-Young TY Arnesen Thomas T Marmorstein Ronen R Oh Goo Taeg GT Lyon Gholson J GJ
eLife 20210806
Amino-terminal acetylation is catalyzed by a set of N-terminal acetyltransferases (NATs). The NatA complex (including X-linked Naa10 and Naa15) is the major acetyltransferase, with 40-50% of all mammalian proteins being potential substrates. However, the overall role of amino-terminal acetylation on a whole-organism level is poorly understood, particularly in mammals. Male mice lacking <i>Naa10</i> show no globally apparent in vivo amino-terminal acetylation impairment and do not exhibit complet ...[more]