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Skeletal muscle wt and OXPHOS inhibited 18 months-old mice treated with edaravone

ABSTRACT: Chronic skeletal muscle mitochondria dyshomeostasis drives tubular aggregate formation. TMT sixplex Isobaric Mass Tagging analysis was carried out in the CBMSO Protein Chemistry Facility (ProteoRed, PRB3-ISCIII and UAM University, Spain.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Soleus, Skeletal Muscle

DISEASE(S): Tubular Aggregate Myopathy 2,Tubular Aggregate Myopathy 1

SUBMITTER: Cristina Sánchez González

LAB HEAD: Laura Formentini

PROVIDER: PXD026722 | Pride | 2022-08-12

REPOSITORIES: Pride

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Chronic inhibition of the mitochondrial ATP synthase in skeletal muscle triggers sarcoplasmic reticulum distress and tubular aggregates.

Sánchez-González Cristina C Herrero Martín Juan Cruz JC Salegi Ansa Beñat B Núñez de Arenas Cristina C Stančič Brina B Pereira Marta P MP Contreras Laura L Cuezva José M JM Formentini Laura L

Cell death & disease 20220622 6

Tubular aggregates (TA) are honeycomb-like arrays of sarcoplasmic-reticulum (SR) tubules affecting aged glycolytic fibers of male individuals and inducing severe sarcomere disorganization and muscular pain. TA develop in skeletal muscle from Tubular Aggregate Myopathy (TAM) patients as well as in other disorders including endocrine syndromes, diabetes, and ageing, being their primary cause unknown. Nowadays, there is no cure for TA. Intriguingly, both hypoxia and calcium dyshomeostasis prompt TA ...[more]

PMID: 35732639

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