Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Cytomegalovirus Homo Sapiens (human)
TISSUE(S): Cell Culture, Fibroblast
DISEASE(S): Human Cytomegalovirus Infection
SUBMITTER: Michael Weekes
LAB HEAD: Michael Weekes
PROVIDER: PXD026785 | Pride | 2022-02-22
REPOSITORIES: Pride
Nightingale Katie K Potts Martin M Hunter Leah M LM Fielding Ceri A CA Zerbe Cassie M CM Fletcher-Etherington Alice A Nobre Luis L Wang Eddie C Y ECY Strang Blair L BL Houghton Jack W JW Antrobus Robin R Suarez Nicolas M NM Nichols Jenna J Davison Andrew J AJ Stanton Richard J RJ Weekes Michael P MP
Proceedings of the National Academy of Sciences of the United States of America 20220201 6
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate, and adaptive immunity. We have employed two orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins down-regulated by viral factors expressed during the latest phases of viral infection. This approach revealed that the HIV-1 restriction factor Schlafen-11 (SLFN11) was degraded by the poorly characterized, late-expressed HCMV protein RL1 ...[more]