Proteomics

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A quantitative proteomics study for assessing rodent thyroid toxicity

ABSTRACT: Here, we aimed to use TMT based quantitative proteomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (high, low) and three treatment time points (short, long, and long+recovery) were investigated, allowing insights into the mode of actions during thyroid toxicity. Proteomics were applied to liver and thyroid tissues.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver, Thyroid Gland

SUBMITTER: Zhipeng Wang  

LAB HEAD: Kristin Schubert

PROVIDER: PXD026835 | Pride | 2024-10-25

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Rattus-norvegicus_uniprot-proteome_reference_29944_20200803_ZW.fasta Fasta
XomeTox_L.mzML Mzml
XomeTox_L.mzid.gz Mzid
XomeTox_L_BP10_F1.raw Raw
XomeTox_L_BP10_F2.raw Raw
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