Dataset Information

Proteomics with blood plasma in woody breast myopathy in broiler

ABSTRACT: Shotgun proteomics was conducted with blood plasma samples collected from woody breast chickens compared with non-woody breast control broilers at 4- and 8 wks of age.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Blood Plasma

SUBMITTER: Byungwhi Kong

LAB HEAD: Byungwhi Kong

PROVIDER: PXD026896 | Pride | 2021-09-07

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Experiment_Core_MaxQuant_Files_TMT1_from_Kong_013119_TMT1_SF01__11_others.mzid.gz	Mzid
	Experiment_Core_MaxQuant_Files_TMT1_from_Kong_013119_TMT1_SF01__11_others.mzid_Experiment_Core_MaxQuant_Files_TMT1_from_Kong_013119_TMT1_SF01__11_others.MGF	Mzid
	Experiment_Core_MaxQuant_Files_TMT1_from_Kong_091518_TMT1_FT__12_others.mzid.gz	Mzid
	Experiment_Core_MaxQuant_Files_TMT1_from_Kong_091518_TMT1_FT__12_others.mzid_Experiment_Core_MaxQuant_Files_TMT1_from_Kong_091518_TMT1_FT__12_others.MGF	Mzid
	Experiment_Core_MaxQuant_Files_TMT2_from_Kong_013119_TMT2_SF01__11_others.mzid.gz	Mzid

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Publications

Blood Plasma Biomarkers for Woody Breast Disease in Commercial Broilers.

Kong Byungwhi B Khatri Bhuwan B Kang Seong S Shouse Stephanie S Kadhim Hakeem H Kidd Michael M Lassiter Kentu K Hiltz Joseph J Mallmann Barbara B Orlowski Sara S Anthony Nicholas N Bottje Walter W Kuenzel Wayne W Owens Casey C

Frontiers in physiology 20210722

Woody breast (WB) myopathy results in poor muscle quality. The increasing incidence of WB over the last several years indicates a need for improved prediction or early diagnosis. We hypothesized that the use of body fluids, including blood, may be more suitable than breast muscle tissue in developing a minimally invasive diagnostic tool for WB detection. To identify potential early-age-biomarkers that may represent the potential onset of WB, blood samples were collected from 100, 4 wks old comme ...[more]

PMID: 34366899

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Project description:Chromosomal structural variation can cause alterations in gene dosage and gene regulation between genomes. Structural variants producing a change in the number of copies of a genomic region are termed copy number variants (CNVs). CNVs have been demonstrated to have causative effects on both Mendelian and complex traits, including susceptibility to infectious diseases. We are interested in mapping CNVs to domesticated chicken breeds to help determine structural variation between genomes that influences economically important traits. For this study, Fayoumi, Leghorn, Line A broiler and Line B broiler chicken were chosen. Fayoumi and Leghorn chickens were selected as these two breeds harbor different responses certain pathogens like Avian Influenza Virus and coccidiosis; Broiler Line A and Line B indivduals were chosen as they harbor different intestinal colonization loads to the bacterium Campylobacter jejuni. Campylobacter genetic Line A and genetic Line B are from a commercial producer have been previously described as either resistant (Line A) or susceptible (Line B). Highly inbred chicken lines Fayoumi M15.2 (n=6) and Leghorn GHs6 (n=6) and broilers from Line A (n=24 individuals in pools of 4) and Line B (n=24 individuals in pools of 4)were subjected to array Comparative Genomic Hybridization (aCGH). Each sample was normalized to a Red Jungle Fowl reference. CNVs for each individual and between lines were determined. The major goal of this study was to discover and characterize CNVs in chickens to further narrow in on Quantitative Trait Loci (QTLs) affecting disease response. For the test DNA in Fayoumi and Leghorn, samples from 6 inbred Fayoumi and 6 inbred Leghorn individuals were used; For the test DNA in the Campylobacter genetic lines, samples from 24 individual broilers of Line A (in pools of 4) and 24 individual broilers of Line B (in pools of 4) were used. For the reference DNA, Red Jungle Fowl line UCD001 was used from a self-self hybridization.