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Analysis of human brain tissue derived from DBS surgery

ABSTRACT: The implantation of deep brain stimulation (DBS) electrodes into the human brain is a neurosurgical treatment for, e.g., movement disorders. We describe a novel approach to collecting brain tissue from DBS surgery-guiding instruments for liquid chromatography-mass spectrometry and RNA sequencing analyses. Proteomics and transcriptomics showed that the approach is useful for obtaining disease-specific expression data. A comparison between our improved and the previous approaches and related datasets was performed. BioStudies:https://www.ebi.ac.uk/biostudies/studies/S-BSST667 and Publication: https://www.biorxiv.org/content/10.1101/2021.06.18.448926v1

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Jaakko Teppo

LAB HEAD: Markku Varjosalo

PROVIDER: PXD026936 | Pride | 2021-06-29

REPOSITORIES: Pride

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