Mouse spleen LC-MSMS from C57BL/6J WT, CD38-deficient and B6.C-H2bm12/KHEg (bm12) mice in cGVHD lupus-like model
Ontology highlight
ABSTRACT:
INSTRUMENT(S): amaZon Speed ETD
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen
DISEASE(S): Systemic Lupus Erythematosus
SUBMITTER: 
Jaime Sancho
LAB HEAD: Jaime Sancho
PROVIDER: PXD026947 | Pride | 2021-10-11
REPOSITORIES: Pride
Publications
CD38 Deficiency Ameliorates Chronic Graft-<i>Versus</i>-Host Disease Murine Lupus <i>via</i> a B-Cell-Dependent Mechanism.
Martínez-Blanco África Á Domínguez-Pantoja Marilú M Botía-Sánchez María M Pérez-Cabrera Sonia S Bello-Iglesias Nerea N Carrillo-Rodríguez Paula P Martin-Morales Natividad N Lario-Simón Antonio A Pérez-Sánchez-Cañete María M MM Montosa-Hidalgo Laura L Guerrero-Fernández Salvador S Longobardo-Polanco Victoria M VM Redondo-Sánchez Sandra S Cornet-Gomez Alberto A Torres-Sáez María M Fernández-Ibáñez Ana A Terrón-Camero Laura L Andrés-León Eduardo E O'Valle Francisco F Merino Ramón R Zubiaur Mercedes M Sancho Jaime J
Frontiers in immunology 20210824
The absence of the mouse cell surface receptor CD38 in <i>Cd38<sup>-/-</sup></i> mice suggests that this receptor acts as a positive regulator of inflammatory and autoimmune responses. Here, we report that, in the context of the chronic graft-<i>versus</i>-host disease (cGVHD) lupus inducible model, the transfer of B6.C-H2bm12/KhEg(bm12) spleen cells into co-isogenic <i>Cd38<sup>-/-</sup></i> B6 mice causes milder lupus-like autoimmunity with lower levels of anti-ssDNA autoantibodies than the tr ...[more]
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