Human tumor pericyte protein mass spectrometry
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Pericyte Cell
DISEASE(S): Non-small Cell Lung Carcinoma
SUBMITTER: 
Xue Jiang
LAB HEAD: Ping-Pui Wong
PROVIDER: PXD026963 | Pride | 2021-08-24
REPOSITORIES: Pride
Publications
Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities.
Meng Ya-Ming YM Jiang Xue X Zhao Xinbao X Meng Qiong Q Wu Sangqing S Chen Yitian Y Kong Xiangzhan X Qiu Xiaoyi X Su Liangping L Huang Cheng C Wang Minghui M Liu Chao C Wong Ping-Pui PP
Nature communications 20211014 1
Defective pericyte-endothelial cell interaction in tumors leads to a chaotic, poorly organized and dysfunctional vasculature. However, the underlying mechanism behind this is poorly studied. Herein, we develop a method that combines magnetic beads and flow cytometry cell sorting to isolate pericytes from tumors and normal adjacent tissues from patients with non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Pericytes from tumors show defective blood vessel supporting function ...[more]
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