Proteomic Identification of Lung Adenocarcinoma and Normal Lung Tissue
Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
DISEASE(S): Lung Adenocarcinoma
SUBMITTER: 
Xu Ran
LAB HEAD: Zhang linyou
PROVIDER: PXD027008 | Pride | 2022-01-12
REPOSITORIES: Pride
Publications
Identification of ubiquitinated substrate proteins and their gene expression patterns in lung adenocarcinoma.
Xu Ran R Lu Tong T Zhao Jiaying J Li Qi Q Wang Jun J Peng Bo B Liu Jian J Zhang Pengfei P Qu Lidong L Chang Xiaoyan X Yao Lingqi L Zhang Linyou L
Annals of translational medicine 20211101 22
<h4>Background</h4>Lung cancer is a malignant disease with the highest cancer-related mortality rate. In lung adenocarcinoma (LUAD), protein ubiquitination can regulate multiple biological processes. A LUAD ubiquitylome analysis has not yet been reported.<h4>Methods</h4>We used for the first time ion mobility into liquid chromatography-mass spectrometry to perform accurate and reliable ubiquitylome and proteomic analysis of clinical LUAD and normal tissues and combined it with transcriptome data ...[more]
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