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Human NSCLC sh-QKI-6 A549 cell label-free quantification and LC/MS proteomics analysis

ABSTRACT: Label-Free Quantitation of Differentially Expressed Proteins in Sh-QKI6 and sh-NC

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: haihua zhang

LAB HEAD: Haihua Zhang

PROVIDER: PXD027013 | Pride | 2022-06-09

REPOSITORIES: Pride

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QKI-6 Suppresses Cell Proliferation, Migration, and EMT in Non-Small Cell Lung Cancer.

Zhang Haihua H Li Junqiang J Tian Feng F Su Xuan X Wang Xinxin X Tang Di D Zhang Lei L Zhang Tao T Ni Yunfeng Y

Frontiers in oncology 20220505

The RNA-binding protein quaking homolog 6 (QKI-6) is a tumor-suppressor gene in several cancers. However, its role in non-small cell lung cancer (NSCLC) is unclear. In this study, we aimed to determine the association between QKI-6 expression and survival and clinicopathological features in patients with NSCLC and identify the related mechanisms. Western blot and immunohistochemistry (IHC) were used to detect QKI-6 expression in NSCLC. The effect of QKI-6 on NSCLC cells was determined by overexp ...[more]

PMID: 35600368

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