Proteomics

Dataset Information

0

Human CK1 alpha (CK1α) 5'UTR-interacting proteins


ABSTRACT: We used tobramycin-affinity RNA-pulldown assays coupled with mass spectrometry to identify CK1α 5'-UTR-binding proteins.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Jit Kong Cheong  

LAB HEAD: Jit Kong Cheong

PROVIDER: PXD027124 | Pride | 2022-10-01

REPOSITORIES: Pride

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Publications


Oncogenic mutations in the RAS family of small GTPases are commonly found in human cancers and they promote tumorigenesis by altering gene expression networks. We previously demonstrated that Casein Kinase 1α (CK1α), a member of the CK1 family of serine/threonine kinases, is post-transcriptionally upregulated by oncogenic RAS signaling. Here, we report that the CK1α mRNA contains an exceptionally long 5'-untranslated region (UTR) harbouring several translational control elements, implicating its  ...[more]

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