Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Epithelial Cell Of Proximal Tubule
DISEASE(S): Kidney Disease
SUBMITTER: Franziska Voellmy
LAB HEAD: Rosalinde Masereeuw
PROVIDER: PXD027142 | Pride | 2022-08-12
REPOSITORIES: Pride
Lindoso Rafael Soares RS Yousef Yengej Fjodor A FA Voellmy Franziska F Altelaar Maarten M Mancheño Juncosa Estela E Tsikari Theano T Ammerlaan Carola M E CME Van Balkom Bas W M BWM Rookmaaker Maarten B MB Verhaar Marianne C MC Masereeuw Rosalinde R
Journal of nanobiotechnology 20220715 1
The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kidney tubule, but still lack the expression of important transport proteins needed for waste removal. Here, we investigated the potential of extracellular vesicles (EVs) obtained from matured kidney tubular epithelial cells to modulate in vitro tubuloids functional maturation. We focused on o ...[more]