Ontology highlight
ABSTRACT:
INSTRUMENT(S): 4800 Proteomics Analyzer
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Haibo Wang
LAB HEAD: Prof. Hongzhe Sun
PROVIDER: PXD027305 | Pride | 2023-05-10
REPOSITORIES: Pride
Wang Haibo H Hu Ligang L Li Hongyan H Lai Yau-Tsz YT Wei Xueying X Xu Xiaohan X Cao Zhenkun Z Cao Huiming H Wan Qianya Q Chang Yuen-Yan YY Xu Aimin A Zhou Qunfang Q Jiang Guibin G He Ming-Liang ML Sun Hongzhe H
Nature communications 20230328 1
Chromium(III) is extensively used as a supplement for muscle development and the treatment of diabetes mellitus. However, its mode of action, essentiality, and physiological/pharmacological effects have been a subject of scientific debate for over half a century owing to the failure in identifying the molecular targets of Cr(III). Herein, by integrating fluorescence imaging with a proteomic approach, we visualized the Cr(III) proteome being mainly localized in the mitochondria, and subsequently ...[more]