Proteomics

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Comparative proteomic profile in duodenum sample of male slow-growing chicken

ABSTRACT: Since the molecular mechanism underlying feed efficiency (FE) in slow-growing chickens is poorly understood. Thus, this study aimed to investigate the proteome differences and possible pathways associated with FE in male slow-growing chicken by using a label-free quantitative proteomic approach. At 10 weeks of ages duodenum samples from six animals (three high-FE and three low-FE chickens) were collected for differential abundant proteins (DAPs), protein networks, functional enrichment and pathway analysis. In this study, we found 40 DAPs significantly associated with FE pathways included glycolysis/gluconeogenesis, peroxisome, oxidative phosphorylation, tight junction, and cysteine and methionine metabolism. Thus, the differences of protein driving those pathways affected the FE potential of slow-growing chicken might be interesting candidate biomarkers for genomic selection of animals with a higher efficient feed utilization.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Duodenum

SUBMITTER: Pramin Kaewsatuan  

LAB HEAD: Amonrat molee

PROVIDER: PXD027317 | Pride | 2022-05-20

REPOSITORIES: Pride

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Comparative proteomics revealed duodenal metabolic function associated with feed efficiency in slow-growing chicken.

Kaewsatuan Pramin P   Poompramun Chotima C   Kubota Satoshi S   Yongsawatdigul Jirawat J   Molee Wittawat W   Uimari Pekka P   Molee Amonrat A  

Poultry science 20220308 6

The Korat chicken (KR), developed in Thailand, is a slow-growing breed developed as an alternative breed for Thai chicken producers. The growing interest in slow-growing chicken meat, due to its unique taste, distinct texture, health benefits, and higher broiler welfare have led to higher market demand for KR. However, its low feed efficiency (FE) has a significant negative impact on farm profitability. Understanding the molecular mechanism regulating FE allows for designing a suitable selection  ...[more]

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