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Compositional analysis of venom in three species of Indian cobra (Naja) and their cross-reactivity with Indian polyvalent Antivenom

ABSTRACT: The study represents genus-wide proteomics analysis of venom composition across Naja (N. naja, N. oxiana and N. kaouthia) found in mainland India. Venoms from Naja species were fractionated using RP-HPLC and subjected to MS/MS analysis. Indian polyvalent antivenom immunoprofiling was performed against different venoms by identifying unbound toxins using MS/MS analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Naja Oxiana Naja Kaouthia Naja Naja

SUBMITTER: siddharth bhatia

LAB HEAD: Anita malhotra

PROVIDER: PXD027361 | Pride | 2023-05-10

REPOSITORIES: Pride

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Multilevel Comparison of Indian Naja Venoms and Their Cross-Reactivity with Indian Polyvalent Antivenoms.

Deka Archana A Bhatia Siddharth S Santra Vishal V Bharti Omesh K OK Lalremsanga Hmar Tlawmte HT Martin Gerard G Wüster Wolfgang W Owens John B JB Graham Stuart S Doley Robin R Malhotra Anita A

Toxins 20230401 4

Snake envenoming is caused by many biological species, rather than a single infectious agent, each with a multiplicity of toxins in their venom. Hence, developing effective treatments is challenging, especially in biodiverse and biogeographically complex countries such as India. The present study represents the first genus-wide proteomics analysis of venom composition across Naja species (N. naja, N. oxiana, and N. kaouthia) found in mainland India. Venom proteomes we ...[more]

PMID: 37104196

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