Dataset Information
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: 
Florian Stieglitz
LAB HEAD: Andreas Pich
PROVIDER: PXD027411 | Pride | 2021-08-25
REPOSITORIES: Pride
Publications
The Binary Toxin of <i>Clostridioides difficile</i> Alters the Proteome and Phosphoproteome of HEp-2 Cells.
Frontiers in microbiology 20210914
<i>Clostridioides difficile</i> is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B. Hypervirulent strains of <i>C. difficile</i> are linked to higher mortality rates and most of these strains produce additionally the <i>C. difficile</i> binary toxin (CDT) that possesses two subunits, CDTa and CDTb. The latter is responsible for binding and transfer of ...[more]
