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JEV NS1'-interacting cellular proteins

ABSTRACT: We identify NS1' interacting proteins via immunopreciptation of JEV-infected cell lysates with an NS1'-specific antibody.

INSTRUMENT(S): Progenesis LC-MS

ORGANISM(S): Homo Sapiens (human) Japanese Encephalitis Virus

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: 秋燕李

LAB HEAD: Deng qin

PROVIDER: PXD027412 | Pride | 2022-02-17

REPOSITORIES: Pride

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Japanese Encephalitis Virus NS1' Protein Interacts with Host CDK1 Protein to Regulate Antiviral Response.

Li Qiuyan Q Zhou Dengyuan D Jia Fan F Zhang Luping L Ashraf Usama U Li Yunchuan Y Duan Hongyu H Song Yunfeng Y Chen Huanchun H Cao Shengbo S Ye Jing J Ye Jing J

Microbiology spectrum 20211110 3

Type I interferon (IFN-I) is a key component of the host innate immune system. To establish efficient replication, viruses have developed several strategies to escape from the host IFN response. Japanese encephalitis virus (JEV) NS1', a larger NS1-related protein, is known to inhibit the mitochondrial antiviral signaling (MAVS)-mediated IFN-β induction by increasing the binding of transcription factors (CREB and c-Rel) to the microRNA 22 (miRNA-22) promoter. However, the mechanism by which NS1' ...[more]

PMID: 34756071

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