Pulmonary artery banded rat heart
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Heart
SUBMITTER: 
Josh Maxwell
LAB HEAD: Josh Maxwell
PROVIDER: PXD027427 | Pride | 2022-05-20
REPOSITORIES: Pride
Publications
Loss of cardiac myosin light chain kinase contributes to contractile dysfunction in right ventricular pressure overload.
Prasad Vidhya V Makkaoui Nour N Rajan Rohan R Patel Alisha A Mainali Bipul B Bagchi Pritha P Kumar Rhea R Rogers Julia J Diamond Jake J Maxwell Joshua T JT
Physiological reports 20220401 7
Nearly 1 in every 100 children born have a congenital heart defect. Many of these defects primarily affect the right heart causing pressure overload of the right ventricle (RV). The RV maintains function by adapting to the increased pressure; however, many of these adaptations eventually lead to RV hypertrophy and failure. In this study, we aim to identify the cellular and molecular mechanisms of these adaptions. We utilized a surgical animal model of pulmonary artery banding (PAB) in juvenile r ...[more]
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