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Uncovering Protein Interacting Partners with lncRNA Gas5

ABSTRACT: To identify proteins that interact with lncRNA Gas5 in hippocampal neurons, we performed a Gas5 pulldown experiment from mouse primary hippocampal cultures and performed LC-MS/MS.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Hippocampal Neuron

DISEASE(S): Disease Free

SUBMITTER: Eddie Grinman

LAB HEAD: Sathya Puthanveettil

PROVIDER: PXD027453 | Pride | 2025-07-28

REPOSITORIES: Pride

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			Action	DRS
	MS221042_AP_AS_AS1.mzid.gz	Mzid
	MS221042_AP_AS_AS1.mzid_MS221042_AP_AS_AS1.MGF	Mzid
	MS221042_AP_AS_AS1.raw	Raw
	MS221042_AP_AS_AS2.mzid.gz	Mzid
	MS221042_AP_AS_AS2.mzid_MS221042_AP_AS_AS2.MGF	Mzid

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1 - 5 of 19

Publications

The lncRNA Gas5 is an activity-responsive scaffold that mediates cAMP-dependent synaptic plasticity.

Chanda Kaushik K Grinman Eddie E Clark Kaylyn K Sadhu Abhishek A Raveendra Bindu B Swarnkar Supriya S Puthanveettil Sathyanarayanan V SV

Science signaling 20250624 892

Changes in the transcriptome are critical in shaping the structural plasticity of neurons, which underpins learning and long-term memory storage. Here, we explored the effect of two opposing, plasticity-associated pathways-cAMP second-messenger signaling and metabotropic glutamate receptor (mGluR1 and mGluR5) signaling-on the transcriptome in hippocampal neurons and how these pathways operate in distinct and coordinated manners to induce structural changes. Integration of transcriptome data and ...[more]

PMID: 40554602

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