Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Endothelial Cell
SUBMITTER: Arie Hoogendijk
LAB HEAD: Maartje van den Biggelaar
PROVIDER: PXD027516 | Pride | 2022-01-27
REPOSITORIES: Pride
Kat Marije M Karampini Ellie E Hoogendijk Arie J AJ Bürgisser Petra E PE Mulder Aat A AA Van Alphen Floris P J FPJ Olins Jenny J Geerts Dirk D Van den Biggelaar Maartje M Margadant Coert C Voorberg Jan J Bierings Ruben R
Haematologica 20220801 8
Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells. VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPB), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongated WPB morphology is correlated to longer VWF strings with better adhesive properties. We previously identified the SNARE SEC22B, which is involved in anterograde endoplasmic reticulum-to-Golgi transport, as a novel ...[more]