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The effect of TCOF1 on renal cancer proteome

ABSTRACT: TCOF1 encodes treacle, a multifunctional protein involved in ribosome biogenesis, regulation of mitosis, proliferation, response to DNA damage, and apoptosis. TCOF1 mutations cause Treacher Collins syndrome, a rare genetic disorder leading to craniofacial malformations. The expression of TCOF1 is disturbed in renal cancer. The global effects of TCOF1 dysfunction in cancer are unknown. Here, we explored the effect of TCOF1 depletion on proteome of renal cancer.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

SUBMITTER: Jacek Wisniewski

LAB HEAD: Jacek R Wisniewski

PROVIDER: PXD027601 | Pride | 2026-05-25

REPOSITORIES: Pride

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	20210621_EXPL3_JRW_SA_L_XX21.raw	Raw
	20210621_EXPL3_JRW_SA_L_XX22.raw	Raw
	20210621_EXPL3_JRW_SA_L_XX23.raw	Raw
	20210621_EXPL3_JRW_SA_L_XX24.raw	Raw
	20210621_EXPL3_JRW_SA_L_XX25.raw	Raw

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Publications

TCOF1 affects Golgi secretory pathway contributing to the angiogenesis in renal cancer.

Grzanka Małgorzata M Popławski Piotr P Wiśniewski Jacek R JR Iwanicka-Nowicka Roksana R Kossowska Helena H Koblowska Marta M Rybicka Beata B Białas Alex A Piekiełko-Witkowska Agnieszka A

Cell communication and signaling : CCS 20260317 1

PMID: 41840584

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Proteomic-based analysis of hypoxia and physioxia responsive proteins and pathways in DLBCLProteomic-based analysis of hypoxia and physioxia responsive proteins and pathways in DLBCL

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