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Cerebrospinal fluid biomarkers in Idiopathic Intracranial Hypertension: an exploratory SWATH proteomics analysis

ABSTRACT: The pathogenesis of idiopathic intracranial hypertension (IIH) is currently poorly understood. Speculations regarding the role of cerebrospinal fluid (CSF) protein biomarkers in understanding the pathomechanism of IIH needs to be studied using the high-throughput omics approaches.In this study we have performed an untargeted SWATH-MS proteomics approach to identify CSF biomarkers in IIH cases compared to control subjects.

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Cerebrospinal Fluid

SUBMITTER: Praveen Singh

LAB HEAD: Awadh Kishor Pandit

PROVIDER: PXD027751 | Pride | 2023-10-24

REPOSITORIES: Pride

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Cerebrospinal fluid proteins in idiopathic intracranial hypertension: An exploratory SWATH proteomics analysis.

Pandit Awadh Kishor AK Misra Shubham S Sengupta Shantanu S Chakraborty Rahul R Singh Praveen P Singh Gyaninder Pal GP Phuljhele Swati S Srivastava Achal K AK Vibha Deepti D Garg Ajay A Shankar Vivek V Mohania Dheeraj D Shukla Garima G Prasad Kameshwar K

Proteomics. Clinical applications 20230807 1

<h4>Purpose</h4>The pathogenesis of idiopathic intracranial hypertension (IIH) is currently poorly understood. This exploratory study aimed to identify potential cerebrospinal fluid (CSF) biomarkers in IIH cases compared to controls using SWATH-MS proteomics approach.<h4>Experimental design</h4>CSF samples were collected prospectively from IIH cases and control subjects which were subjected to SWATH-MS based untargeted proteomics. Proteins with fold change > 1.5 or < 0.67 and p-value < 0.05 were ...[more]

PMID: 37551060

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