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Aging induces hepatic oxidative stress and nuclear proteomic remodelling in liver from Wistar ratAging induces hepatic oxidative stress and nuclear proteomic remodelling in liver from Wistar rats

ABSTRACT: Aging induces oxidative stress and proteome remodeling in the nucleus from liver in Wistar rats

INSTRUMENT(S): Orbitrap Fusion, LTQ Orbitrap Elite

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver

SUBMITTER: Elena Bonzon-Kulichenko

LAB HEAD: Jesús Vázquez

PROVIDER: PXD027773 | Pride | 2022-02-17

REPOSITORIES: Pride

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Aging Induces Hepatic Oxidative Stress and Nuclear Proteomic Remodeling in Liver from Wistar Rats.

Bárcena Brenda B Salamanca Aurora A Pintado Cristina C Mazuecos Lorena L Villar Margarita M Moltó Eduardo E Bonzón-Kulichenko Elena E Vázquez Jesús J Andrés Antonio A Gallardo Nilda N

Antioxidants (Basel, Switzerland) 20210927 10

Aging is a continuous, universal, and irreversible process that determines progressive loss of adaptability. The liver is a critical organ that supports digestion, metabolism, immunity, detoxification, vitamin storage, and hormone signaling. Nevertheless, the relationship between aging and the development of liver diseases remains elusive. In fact, although prolonged fasting in adult rodents and humans delays the onset of the disease and increases longevity, whether prolonged fasting could exert ...[more]

PMID: 34679670

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