Analysis of exosomes secreted during cardiac differentiation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Mesoderm, Early Embryonic Cell, Fetal Cardiomyocyte
SUBMITTER: 
Preeti Ashok
LAB HEAD: Emmanuel Tzanakakis
PROVIDER: PXD027888 | Pride | 2021-11-02
REPOSITORIES: Pride
Publications
Proteomic Analysis of Exosomes during Cardiogenic Differentiation of Human Pluripotent Stem Cells.
Ashok Preeti P Tzanakakis Emmanuel S ES
Cells 20211001 10
Efforts to direct the specification of human pluripotent stem cells (hPSCs) to therapeutically important somatic cell types have focused on identifying proper combinations of soluble cues. Yet, whether exosomes, which mediate intercellular communication, play a role in the differentiation remains unexplored. We took a first step toward addressing this question by subjecting hPSCs to stage-wise specification toward cardiomyocytes (CMs) in scalable stirred-suspension cultures and collecting exosom ...[more]
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