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Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation

ABSTRACT: In this study we assessed the intestinal proteome of Atlantic salmon from four groups that were fed different diets. We employed isobaric tags for relative and absolute quantification and 2D LC-MS/MS approach for quantifying the proteins. The proteins described here can be exploited to alleviate intestinal inflammation in fish and higher vertebrates.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Salmo Salar (atlantic Salmon)

TISSUE(S): Intestine

DISEASE(S): Inflammation

SUBMITTER: Kiron Viswanath

LAB HEAD: Kiron Viswanath

PROVIDER: PXD027922 | Pride | 2022-02-14

REPOSITORIES: Pride

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Clues from the intestinal mucus proteome of Atlantic salmon to counter inflammation.

Kiron Viswanath V Kathiresan Purushothaman P Fernandes Jorge M O JMO Sørensen Mette M Vasanth Ghana K GK Lin Qingsong Q Lin Qifeng Q Lim Teck Kwang TK Dahle Dalia D Dias Jorge J Trichet Viviane Verlhac VV

Journal of proteomics 20220119

Intestinal inflammation in Atlantic salmon was studied by profiling the intestine mucus proteome, employing iTRAQ and 2D LC-MS/MS approach. Two fish groups were fed soy saponin-containing (inflammation inducer) diets (SO and SP) and two control fish groups were fed diets devoid of soy saponin (CO and CP) for 36 days. The CP and SP diets contained a health additive. Inflammation characteristics in the intestine were milder in the SP-fed fish compared to the SO-fed fish. The SO group was character ...[more]

PMID: 35065288

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