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Proteomic analysis in S100A16-overexpressed human gastric cancer cells lines

ABSTRACT: Our studies reveal that S100A16 overexpression triggers GC cells proliferation and migration both in vivo and in vitro; by contrast, S100A16 knockdown restricts the speed of GC cells growth and mobility. Proteomic analysis results reveal a large S100A16 interactome, which includes ZO-2 (Zonula Occludens-2), a master regulator of cell-to-cell tight junction

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Stomach Cancer

SUBMITTER: Xiaoying You

LAB HEAD: Dongming Su

PROVIDER: PXD028022 | Pride | 2022-02-17

REPOSITORIES: Pride

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Calcium Binding Protein S100A16 Expedites Proliferation, Invasion and Epithelial-Mesenchymal Transition Process in Gastric Cancer.

You Xiaoying X Li Min M Cai Hongwei H Zhang Wenwen W Hong Ye Y Gao Wenjie W Liu Yun Y Liang Xiubin X Wu Tijun T Chen Fang F Su Dongming D

Frontiers in cell and developmental biology 20210928

Gastric cancer (GC) is one of the most common malignant tumors of the digestive system, listed as the second cause of cancer-related deaths worldwide. S100 Calcium Binding Protein A16 (S100A16) is an acidic calcium-binding protein associated with several types of tumor progression. However, the function of S100A16 in GC is still not very clear. In this study, we analyzed S100A16 expression with the GEPIA database and the UALCAN cancer database. Meanwhile, 100 clinical GC samples were used for th ...[more]

PMID: 34650982

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RNA Sequencing of three pairs of gastric cancer

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