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Intestinal proteomic response to oral challenge of enterotoxigenic Escherichia coli in weaned pigs

ABSTRACT: Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea in children in resource-limited countries and of travellers diarrhoea. The ileal proteomics change after ETEC challenge is less characterised. Here in this study changes of ileal proteins post ETEC challenge in weaned pigs are studied. In total, 5151 ileal proteins were successfully annotated and 9 proteins had significantly different abundance between the ETEC and CON pigs.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Sus Scrofa (pig)

TISSUE(S): Ileum

SUBMITTER: Shanshan Peng

LAB HEAD: Ping-ping Jiang

PROVIDER: PXD028066 | Pride | 2022-04-01

REPOSITORIES: Pride

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Intestinal and Mucosal Microbiome Response to Oral Challenge of Enterotoxigenic Escherichia coli in Weaned Pigs.

Peng Shan-Shan SS Li Yingjie Y Chen Qiuhong Q Hu Qi Q He Ying Y Che Lianqiang L Jiang Ping-Ping PP

Pathogens (Basel, Switzerland) 20220126 2

Enterotoxigenic Escherichia coli (ETEC) is closely associated with diarrhoea in children in resource-limited countries. This study aims to investigate the change of the mucosal microbiome and protein expression in the ileum induced by E. coli K88 (ETEC) using pigs as a model. Seven weaned male pigs were orally given ETEC (1 × 109 CFU, n = 7), and the other seven received saline (CON, n = 7). Ileal tissues were obtained 48 hours after the ETEC challenge for ...[more]

PMID: 35215105

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