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Human LMO2 binding protein LC-MSMS in U87MG(Glioblastoma cell)

ABSTRACT: To identify the binding partner of LMO2 for explanation of STAT3 signal-related protein in human glioblastoma

INSTRUMENT(S): LCQ Classic

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Brain Glioblastoma Multiforme

SUBMITTER: Sang-Hun Choi

LAB HEAD: Hyunggee Kim

PROVIDER: PXD028254 | Pride | 2022-08-11

REPOSITORIES: Pride

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Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells.

Park Cheol Gyu CG Choi Sang-Hun SH Lee Seon Yong SY Eun Kiyoung K Park Min Gi MG Jang Junseok J Jeong Hyeon Ju HJ Kim Seong Jin SJ Jeong Sohee S Lee Kanghun K Kim Hyunggee H

Cells 20220626 13

The oncogenic role of nuclear LIM domain only 2 (LMO2) as a transcriptional regulator is well established, but its function in the cytoplasm is largely unknown. Here, we identified LMO2 as a cytoplasmic activator for signal transducer and activator of transcription 3 (STAT3) signaling in glioma stem cells (GSCs) through biochemical and bioinformatics analyses. LMO2 increases STAT3 phosphorylation by interacting with glycoprotein 130 (gp130) and Janus kinases (JAKs). LMO2-driven activation of STA ...[more]

PMID: 35805116

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