Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell
DISEASE(S): Lymphoma
SUBMITTER: Rune Matthiesen
LAB HEAD: Rune Matthiesen
PROVIDER: PXD028267 | Pride | 2021-11-04
REPOSITORIES: Pride
Carvalho Ana Sofia AS Baeta Henrique H Henriques Andreia F A AFA Ejtehadifar Mostafa M Tranfield Erin M EM Sousa Ana Laura AL Farinho Ana A Silva Bruno Costa BC Cabeçadas José J Gameiro Paula P Silva Maria Gomes da MGD Beck Hans Christian HC Matthiesen Rune R
International journal of molecular sciences 20211012 20
The role of extracellular vesicles (EVs) proteome in diffuse large B-cell lymphoma (DLBCL) pathology, subclassification, and patient screening is unexplored. We analyzed by state-of-the-art mass spectrometry the whole cell and secreted extracellular vesicles (EVs) proteomes of different molecular subtypes of DLBCL, germinal center B cell (GCB subtype), and activated B cell (ABC subtype). After quality control assessment, we compared whole-cell and secreted EVs proteomes of the two cell-of-origin ...[more]