Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Intrahepatic Cholangiocyte, Liver
SUBMITTER: Oskar Rosmark
LAB HEAD: Prof. Luc van der Laan
PROVIDER: PXD028417 | Pride | 2022-04-13
REPOSITORIES: Pride
Biomaterials 20220324
Human cholangiocyte organoids are promising for regenerative medicine applications, such as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor-derived basement membrane extracts (BME), which is poorly defined, highly variable and limits the direct clinical applications of organoids in patients. Extracellular matrix (ECM)-derived hydrogels prepared from decellularized human or porcine livers are attractive alternative culture substrates. Here, the culture and e ...[more]