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Cannabidiol displays proteomic similarities to antipsychotics in cuprizone-exposed human oligodendrocytic cell line MO3.13

ABSTRACT: We employed nano-chromatography coupled with mass spectrometry to investigate the proteomic response to benztropine,cannabidiol, clozapine, and haloperidol, both in healthy oligodendrocytic cells and in a cuprizone-based toxicity model, using the human oligodendrocyte precursor cell line MO3.13.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oligodendrocyte Precursor Cell, Cell Culture

DISEASE(S): Schizophrenia

SUBMITTER: Ana Caroline Brambilla Falvella

LAB HEAD: Daniel Martins-de-Souza

PROVIDER: PXD028419 | Pride | 2021-11-11

REPOSITORIES: Pride

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Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13.

Falvella Ana Caroline Brambilla ACB Smith Bradley Joseph BJ Silva-Costa Licia C LC Valença Aline G F AGF Crunfli Fernanda F Zuardi Antonio W AW Hallak Jaime E JE Crippa José A JA de Almeida Valéria V Martins-de-Souza Daniel D

Frontiers in molecular neuroscience 20210528

Cannabidiol, a compound of <i>Cannabis sativa</i>, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are customarily used to manage schizophrenia symptoms. While oligodendrocytes are known to be relevant targets of antipsychotics, the biochemical knowledge in this regard is still limited. Here we evaluated the molecular pathways modulated by ...[more]

PMID: 34122009

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