Extracellular vesicles are crucial mediators in orchestrating brain development and disease

ABSTRACT: Extracellular vesicles have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. In this project, we focus on the physiological characterization, dynamic and function of human EVs during human brain development using human-derived cerebral organoids, neural progenitors, neurons and astrocytes. We examined the composition and function of EVs, in patients with myoclonic epilepsy and find alterations in size, composition and function. This study sheds new light on the biology of EVs during brain development.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebral Cortex Neuron, Astrocyte Of The Cerebral Cortex, Cell Culture, Neural Progenitor Cell

DISEASE(S): Progressive Myoclonus Epilepsy 1a

SUBMITTER: Giuseppina Maccarrone  

LAB HEAD: Silvia Cappello

PROVIDER: PXD028438 | Pride | 2023-07-20

REPOSITORIES: Pride