Dataset Information
Guillain-Barré syndrome following Zika virus infection is associated with a diverse spectrum of peripheral nerve reactive antibodies
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human) Rattus Rattus (black Rat)
TISSUE(S): Cell Culture, Blood Serum, Electrically Active Cell
DISEASE(S): Neuroblastoma
SUBMITTER: 
Georgina Berridge
LAB HEAD: Roman Fischer
PROVIDER: PXD028476 | Pride | 2023-03-10
REPOSITORIES: Pride
Publications
Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies.
Neurology(R) neuroimmunology & neuroinflammation 20221121 1
<h4>Background and objectives</h4>Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rodent and human live cellular models to screen for anti-peripheral nerve reactive IgG and IgM autoantibodies in the sera of patients with ZIKV w ...[more]
