Dataset Information

Human_HeLa endogenous KCTD7_IP-MS

ABSTRACT: endogenous KCTD7 were tagged by FLAG and then purified by TAP with FLAG M2 beads. The then sbujected to MS to ananlyze the interaction proteins with KCTD7.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Wang Yalan

LAB HEAD: Chenji Wang

PROVIDER: PXD028479 | Pride | 2022-10-13

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Lumos03925-SKY-WHY-WYL-20210824-F-K7_20210901184801.msf	Msf
	Lumos03925-SKY-WHY-WYL-20210824-F-K7_20210901184801.raw	Raw

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Publications

KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses.

Wang Yalan Y Cao Xiaotong X Liu Pei P Zeng Weijia W Peng Rui R Shi Qing Q Feng Kai K Zhang Pingzhao P Sun Huiru H Wang Chenji C Wang Hongyan H

Science advances 20220803 31

Lysosomes are central organelles for cellular degradation and energy metabolism. Neuronal ceroid lipofuscinoses (NCLs) are a group of the most common neurodegenerative lysosomal storage disorders characterized by intracellular accumulation of ceroid in neurons. Mutations in <i>KCTD7</i>, a gene encoding an adaptor of the CUL3-RING E3 ubiquitin ligase (CRL3) complex, are categorized as a unique NCL subtype. However, the underlying mechanisms remain elusive. Here, we report various lysosomal and a ...[more]

PMID: 35921411

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