Dataset Information
AKAP2 interactome in the rat heart
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Heart
SUBMITTER: 
Manfredo Quadroni
LAB HEAD: Dario Diviani
PROVIDER: PXD028514 | Pride | 2022-02-16
REPOSITORIES: Pride
Publications
A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial Infarction.
Cells 20211023 11
Myocardial infarction (MI) is a leading cause of maladaptive cardiac remodeling and heart failure. In the damaged heart, loss of function is mainly due to cardiomyocyte death and remodeling of the cardiac tissue. The current study shows that A-kinase anchoring protein 2 (AKAP2) orchestrates cellular processes favoring cardioprotection in infarcted hearts. Induction of AKAP2 knockout (KO) in cardiomyocytes of adult mice increases infarct size and exacerbates cardiac dysfunction after MI, as visua ...[more]