Dataset Information
The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Castor Canadensis Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: 
Gregory Tombline
LAB HEAD: Vera Gorbunova
PROVIDER: PXD028546 | Pride | 2022-02-16
REPOSITORIES: Pride
Publications
Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.
Cell reports 20211101 6
The North American beaver is an exceptionally long-lived and cancer-resistant rodent species. Here, we report the evolutionary changes in its gene coding sequences, copy numbers, and expression. We identify changes that likely increase its ability to detoxify aldehydes, enhance tumor suppression and DNA repair, and alter lipid metabolism, potentially contributing to its longevity and cancer resistance. Hpgd, a tumor suppressor gene, is uniquely duplicated in beavers among rodents, and several ge ...[more]
