Proteomics

Dataset Information

0

Mitochondrial aconitase (ACO2) modulates iron homeostasis and is associated with outcomes in poor prognosis aggressive non-small cell lung cancer


ABSTRACT: NSCLC accounts for 85% of lung cancers, the most frequently diagnosed and leading cause of cancer related death. An ACO2-iron acis regulates intracellular iron and consequently the particularly aggressive phenotype associated with NSCLC engraftment and poor prognosis. These findings suggest that NSCLC stratified by ACO2 protein level may benefit from treatments that target iron homeostasis.

INSTRUMENT(S): LTQ Orbitrap, Q Exactive HF

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Lung, Epithelial Cell

DISEASE(S): Non-small Cell Lung Carcinoma

SUBMITTER: Shideh Mirhadi  

LAB HEAD: Michael F. Moran

PROVIDER: PXD028556 | Pride | 2022-09-19

REPOSITORIES: Pride

Similar Datasets

2015-09-14 | PXD002556 | Pride
2020-08-25 | PXD017530 | Pride
2016-08-25 | PXD000332 | Pride
2011-04-22 | E-GEOD-28813 | biostudies-arrayexpress
2015-03-06 | E-GEOD-59792 | biostudies-arrayexpress
2017-11-08 | E-MTAB-4893 | biostudies-arrayexpress
2019-08-05 | PXD012113 | Pride
2019-07-29 | PXD009766 | Pride
2018-08-06 | PXD007705 | Pride
2016-01-05 | PXD002619 | Pride