Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Endocervix, Epithelial Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: Nicola Ternette
LAB HEAD: Nicola Ternette
PROVIDER: PXD028738 | Pride | 2023-03-11
REPOSITORIES: Pride
Peng Xu X Woodhouse Isaac I Hancock Gemma G Parker Robert R Marx Kristina K Müller Julius J Salatino Silvia S Partridge Thomas T Nicastri Annalisa A Liao Hanqing H Kruppa Gary G Hellner Karin K Dorrell Lucy L Ternette Nicola N
iScience 20230202 3
Current immunotherapeutic approaches for human papillomavirus (HPV)-driven cervical cancer target the viral oncogenes E6 and E7. We report viral canonical and alternative reading frame (ARF)-derived sequences presented on cervical tumor cells, including antigens encoded by the conserved viral gene E1. We confirm immunogenicity of the identified viral peptides in HPV-positive women, and women with cervical intraepithelial neoplasia. We observe consistent transcription of the E1, E6, and E7 genes ...[more]