Proteomics

Dataset Information

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Raptor and rapamycin dependent proteomic changes in Akt overexpressing skeletal muscle


ABSTRACT: Analysis of proteomic changes upon deletion of Raptor or inhibition by rapamycin in mouse muscles over expressing a constitutively active Akt.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle

SUBMITTER: Frederik Tellkamp  

LAB HEAD: Bert Blaauw

PROVIDER: PXD028796 | Pride | 2022-08-08

REPOSITORIES: Pride

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Publications

Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy.

Baraldo Martina M   Nogara Leonardo L   Dumitras Georgia Ana GA   Tchampda Dondjang Achille Homère AH   Geremia Alessia A   Scalabrin Marco M   Türk Clara C   Telkamp Frederik F   Zentilin Lorena L   Giacca Mauro M   Krüger Marcus M   Blaauw Bert B  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20211201 12


Loss of skeletal muscle mass and force is of critical importance in numerous pathologies, like age-related sarcopenia or cancer. It has been shown that the Akt-mTORC1 pathway is critical for stimulating adult muscle mass and function, however, it is unknown if mTORC1 is the only mediator downstream of Akt and which intracellular processes are required for functional muscle growth. Here, we show that loss of Raptor reduces muscle hypertrophy after Akt activation and completely prevents increases  ...[more]

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