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Identification of novel blood protein biomarkers in infants with Acute Intracranial Hemorrhage

ABSTRACT: Abusive head trauma (AHT) is a leading cause of mortality and morbidity in infants. We explored novel AHT biomarkers via untargeted proteomics of peripheral postmortem blood (PMB) specimens collected during medico-legal autopsies of infants. The panel of PMB biomarkers was confirmed in antemortem serum samples as a potential signature capable of being applied to living patients to support AHT screening and improve their prognosis through early medical care.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood Serum, Blood

DISEASE(S): Wounds And Injuries

SUBMITTER: Tatjana Sajic

LAB HEAD: Prof. Aurelien Thomas

PROVIDER: PXD028801 | Pride | 2023-01-07

REPOSITORIES: Pride

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Blood proteome of acute intracranial hemorrhage in infant victims of abusive head trauma.

Wiskott Kim K Gilardi Federica F Hainard Alexandre A Sanchez Jean-Charles JC Thomas Aurelien A Sajic Tatjana T Fracasso Tony T

Proteomics 20230115 3-4

Abusive head trauma (AHT) is a leading cause of mortality and morbidity in infants. While the reported incidence is close to 40 cases per 100'000 births/year, misdiagnoses are commonly observed in cases with atypical, subacute, or chronic presentation. Currently, standard clinical evaluation of inflicted intracranial hemorrhagic injury (ICH) in infants urgently requires a screening test able to identify infants who need additional investigations. Blood biomarkers characteristic of AHT may assist ...[more]

PMID: 36576318

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