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Differential proteomics between AFP-negative HCC and adjacent non-tumor liver tissue

ABSTRACT: We screened and identified novel proteins in AFP-negative HCC tissue that were differentially expressed related to levels in adjacent non-tumor liver tissue using SWATH-MS proteome technology

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Ting Wang

LAB HEAD: Beijing Institute of Hepatology, Beijing You’an Hospital

PROVIDER: PXD028854 | Pride | 2021-11-02

REPOSITORIES: Pride

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Publications

Serum Anti-14-3-3 Zeta Autoantibody as a Biomarker for Predicting Hepatocarcinogenesis.

Wang Ting T Huang Xue-Ying XY Zheng Su-Jun SJ Liu Ye-Ying YY Chen Si-Si SS Ren Feng F Lu Jun J Duan Zhong-Ping ZP Liu Mei M

Frontiers in oncology 20211015

Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Alpha-fetoprotein (AFP) is still the only serum biomarker widely used in clinical settings. However, approximately 40% of HCC patients exhibit normal AFP levels, including very early HCC and AFP-negative HCC; for these patients, serum AFP is not applicable as a biomarker of early detection. Thus, there is an urgent need to identify novel biomarkers for patients for whom disease cannot be diagnosed early. In this study, we screened ...[more]

PMID: 34722278

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