Dataset Information
Cardiac Extracellular Matrix Proteomics of Ang II treated mice.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
SUBMITTER: 
Javier Barallobre-Barreiro
LAB HEAD: Javier Barallobre-Barreiro
PROVIDER: PXD028887 | Pride | 2021-12-15
REPOSITORIES: Pride
Publications
Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling.
Circulation 20211122 25
<h4>Background</h4>Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one of the most abundant proteases. ADAMTS5 cleaves chondroitin sulfate proteoglycans such as versican. The contribution of ADAMTS5 and its substrate versican to HF is unknown.<h4>Methods</h4>Versican remodeling was assessed in mice lacking th ...[more]
