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Proteomic analysis of human SKBR3/HER2+ breast cancer cell-surface proteins by using tryptic shaving

ABSTRACT: The plasma membrane proteome resides at the interface between the extra- and intra-cellular environment and through its various roles in signal transduction, immune recognition, nutrient transport, and cell-cell and cell-matrix interactions plays a critical role in determining the fate of a cell. The objective of this study was to characterize the cell-membrane proteome of SKBR3/HER2+ breast cancer cells by using mass spectrometry detection, to advance the understanding of biological triggers that sustain aberrant cell survival, proliferation, and development of resistance to therapeutic drugs.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Arba Karcini

LAB HEAD: Iulia M. Lazar

PROVIDER: PXD028978 | Pride | 2022-07-11

REPOSITORIES: Pride

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A Molecular Portrait of the Homologous Recombination DNA Repair via Genome-wide Transcriptome Profiling

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